Waypoints The Help Panel
Waypoints and the World Panel
Wraeclast is pretty big, and is full of places you'll want to visit and revisit. To help you get around, the land is dotted with 'Waypoints' which let you quickly travel to destinations you have previously visited. To use a waypoint, activate it and select where you would like to travel. You can only travel to waypoints you've activated previously, so it is always worth activating new waypoints when you come across them.
The World Panel:
When you click on a waypoint, the panel that pops up is called the World Panel. It doesn't just show your waypoints, however; It also displays every area you have previously visited, as well as some connected areas you haven't been to yet. Your quests are listed below the map, and by selecting one you can highlight the path that you need to follow to complete it. Because areas in Path of Exile have varying degrees of random generation, you may not always recognize the layout of an area, even if you've been there several times. The minimap or map overlay may also be different and will need to be revealed again. This may take some getting used to, but it means no two playthroughs are exactly the same.